How to Plan for the Obesity Drug Revolution

Analysis February 27, 2024 at 01:37 PM
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What You Need To Know

  • Life insurers are starting to think about what Wegovy, Saxenda and successors could do for your clients.
  • Fewer obesity-related health complications could mean many clients will have different long-term financial planning needs.
  • The drugs still come with high costs, unpleasant side effects, and the possibility that they will work better for some people than others in the long term.
A scale

Many of your clients who are now struggling with their weight could soon be thin, thanks to the new "glucagon-like peptide-1 agonist" drugs and other weight-loss drugs that show up in the future.

The new drugs, Wegovy and Saxenda, have stunned weight-loss experts who once argued that willpower was the only sensible defense against obesity by helping people lose a substantial amount of their weight without much extra effort. Novo Nordisk says weekly use of the drug cuts the risk of heart attack and stroke by about 20%.

Even better drugs could soon emerge. Eli Lily's tirzepatide, a newly approved GLP-1 agonist sold as Zepbound, led to an average bodyweight loss of 21%.

Insurers and their reinsurers have seen enthusiasm about weight-loss wonder drugs come and go for decades, but now medical experts at Gen Re, Reinsurance Group of America, Munich Re, Scor and Swiss Re are starting to let their guard down and wonder what might happen if the GLP-1 agonists really work, and keep working.

Dr. Gina Guzman, chief medical director at Munich Re Life North America, wrote the article, "Have We Found the Cure to End Obesity?" for Munich Re Life US in June 2023, and " Could obesity drugs reduce heart disease?" for the company earlier this month.

" It's a very exciting time," Guzman said last week in an interview.

She pointed out that about 50% of Americans are obese and 70% weigh more than they should.

"Something has to be done to bend the curve," Guzman said.

What it means: For your clients with weight problems, death and taxes may still be inevitable, but obesity might not be.

The backdrop: Doctors use the body mass index as a rough indicator of how a patient's weight compares with the optimal weight. BMI is equal to the patient's weight in kilograms divided by the square of the patient's height.

The standard U.S. BMI cutoffs are 25 kilograms per square meter for overweight (Guzman uses 27), 30 for obesity and 40 for severe obesity.

In 2019, about 7.6% of U.S. adults suffered from severe obesity, according to the U.S. Government Accountability Office.

GAO investigators found nine anti-obesity drugs on the U.S. market in 2019, including phentermine, a drug that has been approved by the federal Food and Drug Administration since 1959.

Another drug, a combination of phentermine and topiramate, has been approved since 2012 and costs much less than Wegovy or Saxenda but is classified by the FDA as potentially habit-forming.

Both doctors and patients are more excited about the GLP-1 agonists because, at this point, they seem to be safer and more effective than the older weight-loss drugs.

The FDA approved liraglutide, the drug that Novo Nordisk sells as Saxenda, in 2014. It approved semaglutide, the drug the company sells as Wegovy, as a weight-loss drug in 2021.

Companies have also been selling versions of the GLP-1 agonists as type 2 diabetes control drugs for about 20 years.

One obstacle is that Wegovy and Saxenda are both injectable drugs, but Novo Nordisk is already selling an oral form of semaglutide, Rybelsus, for people with type 2 diabetes.

Doctors wrote prescriptions for Wegovy, Saxenda and similar drugs for about 9 million Americans in the last quarter of 2022, according to Trilliant Health, a health data analysis firm.

Concerns: Guzman noted in her articles for Munich Re that Wegovy and Saxenda can cause side effects, including nausea, vomiting, diarrhea, pancreatitis, and kidney and liver damage.

"A study last year reported that 50.3% of adults with type 2 diabetes who were prescribed GLP-1 receptor agonists discontinued the medication within one year," Guzman wrote

The GLP-1 agonist discontinuation rate was higher than that for any other class of diabetes medication, Guzman added.

Health care policymakers are worried about the kind of hype that once boosted opioid sales.

Sen. Chuck Grassley, R-Iowa, complained in March 2023 that Dr. Fatima Cody Stanford, a nominee for the federal 2025-2030 Dietary Guidelines Advisory Committee, had received tens of thousands of dollars from the makers of weight-loss and obesity drugs, including the makers of semaglutide and Ozempic.

Still another concern is cost.

The full list price of Wegovy is about $16,000 per year, according to GoodRx Health.

In August 2023, Francesca Lim of Columbia University and other researchers reported in JAMA Network Open that semaglutide works better than a phentermine-topiramate combination drug to reduce obese adolescents' weight.

But the phentermine-topiramate combination is so much cheaper that it probably adds a healthy year to an obese adolescent's life for just $60,000, compared with a cost of $1.1 million for an extra year of healthy life for Wegovy.

GLP-1 agonist insurance coverage: In 2019, the GAO estimated that about 660,000 Americans had used prescription weight-loss drugs from 2012 through 2016.

Private insurance paid for the drugs for 25% of those patients. Medicaid paid for the drugs for 4% of the patients and Medicare paid for the drugs for 2%.

Today, many public and private plans are starting to pay for GLP-1 agonists for at least some patients, in spite of the high cost.

In California, for example, UnitedHealth's Optum Rx will cover Wegovy for large employer plan enrollees who go through a preauthorization process.

Anthem will cover the drug through some plans for patients who are obese or who are overweight and have high blood pressure, high blood cholesterol levels or diabetes.

Mississippi and Virginia are examples of states that cover GLP-1 agonists through their states' Medicaid plans.

Washington state lawmakers are considering Senate Bill 6182, a bill that could add coverage for GLP-1 agonists to that state's public employee health plan and Medicaid plans.

The Association of Washington Health Care Plans opposes Senate Bill 6182, based on the argument that a GLP-1 agonist mandate would drive up coverage costs.

Some of the resistance to expanding GLP-1 agonist coverage has more to do with concerns about safety than cost.

"While studies have demonstrated significant weight-loss among carefully selected patients while patients have remained on these drugs, their impact on health long term continues to being studied," Virginia Medicaid program managers note in their discussion of GLP-1 agonist coverage.

Medicare Part D prescription drug plans do not cover GLP-1 agonists, because federal law prohibits Medicare from paying for weight-loss drugs.

Rep. David Schweikert, R-Ariz., the vice chair of the congressional Joint Economic Committee, argues in the committee's latest annual report that Medicare should cover weight-loss drugs.

Roughly one-quarter of the federal government's $900 billion in annual spending on Medicare goes toward treating conditions related to obesity, and people with severe obesity have an average of $9,591 in extra health costs per year, according to Schweikert.

The Senate version of a bill that would let Medicare plans cover weight-loss drugs, the Treat and Reduce Obesity Act of 2023, has 11 Republican co-sponsors and nine Democratic co-sponsors. The House version has 46 Democratic co-sponsors and 23 Republican co-sponsors.

When Reinsurance Group of America held its earnings call for the third quarter of 2023, a securities analyst asked compny executives about how the new weight-loss drugs might affect life insurance claims.

It's probably too early to tell what the long-term impact is," Jonathan Porter, RGA's global chief risk officer, said. "But certainly we're encouraged by the potential effects on both mortality and morbidity."

GLP-1 agonists vs. statins: Guzman has already seen another class of miracle drugs in action: statins.

Statins help prevent heart disease by holding down people's blood cholesterol levels.

One big difference between statins and GLP-1 agonists is that statins take months to have much of an effect, and GLP-1 agonists cause a noticeable reduction in weight in just a few weeks, Guzman said.

The future: Guzman noted that even giant reinsurers depend on outside drug safety research and that insurers should not push people to take a new drug like a GLP-1 agonist.

"This drug has side effects," she said.

She also believes that health care providers and health insurers will have to emphasize traditional kinds of health and weight-loss advice, not just hand out drugs.

She noted that, when she goes to Germany or the Netherlands to work with Munich Re colleagues, "they're way thinner than we are" in the United States.

In addition to eating differently, people there are more likely to bike, and they are much more likely to use stairs rather than escalators or elevators, she said.

But insurers can spread awareness of the existence of the new drugs and start to analyze the implications, Guzman said.

Munich Re, for example, is now coming up with techniques to analyze how the spread of successful weight-loss drugs could affect commercial insurance claims, Guzman said.

What planners can do: Here are five recommendations for insurance, financial and retirement advisors, based on interviews with experts.

1. Offer information. Including information about the new drugs in blog posts or offering discussions about the drugs at seminars might be a good way to get attention.

2. Be tactful. Clients who are obese might not be happy to see financial professionals cheerfully offering them advice about their obesity.

3. Avoid collecting and storing information about clients' weight. Weight information is personal health information and is covered by the Health Insurance Portability and Accountability Act. Given all of the hacking going on, the last thing financial professionals need is for a list of clients' names, email addresses and estimated weights to show up for sale on the dark web.

4. Plan for increased uncertainty about life expectancy. If the new drugs really affect people's life expectancy, researchers could discover that obesity is really a group of health problems, not just one health problem, and the new drugs could help some people lot more than others. That means that the weight-loss drugs could add years to the lives of some clients but do nothing for the life expectancy of others.

5. Consider shifts in resource needs. The clients who do benefit from the weight-loss drugs might need less protection for premature death or disability, but they might need more cash later in life for the kinds of interests that healthy, active people enjoy, such as traveling and going out to eat.

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